Major Update
Today marks the major update of Simtiva to V4. A long hiatus occurred between V3 and V4, the development of this change was in progress for one year. The main reason for the time spent in development was the introduction of a "complex mode", or a dual mode, which propofol and opioid (remifentanil or fentanyl) simulations can be run simultaneously. The unique advantage of having a "complex mode" is to explore the pharmacodynamic (PD) interaction between these the hypnotic-analgesic combination. A preset endpoint, the probability of tolerance to laryngoscopy (PTOL) was chosen as the measure to quantify the combined effect of these two drugs. A isobologram chart allows the user to explore different combinations of propofol-remifentanil to achieve the exact same PD effect along the same isobole curve. Moreover, the isobologram chart is sensitive to time, as time progresses, the current time point, as marked by a bright red dot, will move on the screen, with the past an