Changelog

This is a project in active development.

Last updated: 17 Aug, 2024

Version 4.81 (Build 111, Aug 2024)

  • Updated manual (v2.0) to add chapter on Advanced Features & Eleveld Emulation
  • Improved graph dimensions on computer/widescreen devices
  • Corrected minor issues (incorrect reference for pharmacodynamic interaction, arrow symbol in complex mode, bug on loading complex mode simfile)

Version 4.8 (Build 109, May 2024)

  • Feature: Emulation of Eleveld model when using Marsh/Schnider model
  • Feature: Adjusted body weight for Marsh & Schnider with information prompt
  • BW validation: only extreme BMI (e.g. BMI>=35) will trigger warning screen
  • UI/UX: Omitted the "I confirm" and "Disclaimer" check on front screen
  • Bugfixes: error in displaying model parameters after re-selecting a model

 Version 4.7 (Build 102, Mar 2024)

  •  Bugfixes: graph options, eBIS after pause
  •  Infusion duration increased to 6 hours (previously 2 hours)
  •  User Manual: initial release

 Version 4.6 (Build 100, Feb 2024) 

  • Model: Eleveld "without opioid" is added.
  • Control panel: controls the timeline. Quick reset: reset the infusion data. Pause: pause the simulation at current time instance. Jump: jump forward or backward in time

Version 4.5 (Build 97, Jan 2024) 

  • Updated the UI for CPT and CET modes with more compact interface design
  • Sophisticated "preview box" can be viewed by clicking "expand" - previews the full scheme ahead for CPT/CET modes
  • Corrected the CPT algorithm - previously, increasing CPT will overshoot the CP and decreasing the CPT will cause premature re-start of infusion
  • Improved support for widescreen devices particularly in complex/dual mode
  • Bugfix in Safari browser, MacOS

Version 4.4 (Dec 2023)

  • Bolus/Infusion unit function: manual mode - can change infusion unit from "ml/h" to "mg/kg/h" (or appropriate units) & change the bolus unit from "mg" to "mg/kg" or "ml" (or appropriate units)
  • Corrected algorithm in decremental infusion rates for reducing target in CET mode

Version 4.3 (Dec 2023)

  • "Quick edit CeT and CpT" in Fullscreen mode
  • Export/import module - sim-files can be exported to a .CSV file and imported back to SimTIVA or loaded into spreadsheet program. Contains individual weblinks for each sim to replay the sim in a browser.
  • Interface improvements: added ML in preview of CpT and CeT modes, labels of axes in chart
  • Pharmacology: bug fix for fentanyl

Version 4.1 (Nov 2023)

  • Fullscreen mode: Shows current infusion regimen (rates + bolus) in the graph over time; helps to visualize the relationship between CP/CE and changes in infusion dosing
  • UI/UX: iPhone user interface dramatically improved
  • Pharmacology: added alfentanil (Maitre)

Version 4.0 (Sep 2023)

  • Complex mode : two drug regimen and pharmacodynamic interaction using "PTOL" index - probability of tolerance to laryngoscopy 
  • eBIS for eleveld model: Ce propofol relates to estimated BIS based on PD modelling given by eleveld model
  • Improved chart functions: charts can now extend beyond the standard 20min limit as in the last version. The time axis can now be adjusted by user.
  • Paediatric mode: allows entry of age in days, weeks, or months; allows entry of postmenstrual age in premature kids (valid for <6month old infant for eleveld model- PMA will affect clearance)

Version 3.2 (Aug 2022)

  • Pharmacology: Added Fentanyl (Shafer) model, with or without weight adjustment according to formulas by Shibutani

Version 3.1 (May 2022)

  • Feature: "Share" module and separate Viewer App
  • Feature: "Save" functionality with automatically saving simfiles and ability to rescue the last saved simfile or to load previous simfiles
  • Feature: Added add/remove/edit events functionality

Version 3 (Jan 2022)

  • Feature: Time and volume estimation modules
  • Design: Dark mode theme
  • Design: Updated chart engine and related coding to ensure compatibility with ChartJS v3.7.1; this improves speed of charting 
Version 2.1 (Aug 2021)
  • Design: Improves display of CP, CE and infusion rate on top bar of screen
  • Feature/Design: Added screen wake-lock function (screen always on when app active) (supported device only)

Version 2 (Jul 2021)

  • Feature: Added wake-up time (decrement time) prediction module
  • Feature: Added data validation, prompting for invalid model, BMI and weight validation for data input
  • Feature: Added device notification and sound notification (supported device only)
  • Feature: Added remifentanil models (Minto, Eleveld)

Version 1 (Feb 2021)

  • Feature: Added CET mode
  • Feature: Added retrospective correction module
  • Pharmacology: Added Eleveld model and Paedfusor model for propofol
  • Design: responsive design and allow appropriate display on landscape and portrait screen orientation across all screen sizes

Version 0.1 (Nov 2020)

  • Initial release
  • CPT mode and manual mode available
  • Marsh, Schnider models available


Comments

Post a Comment

Popular posts from this blog

Origin

Welcome to SimTIVA blog.  SimTIVA is a program which simulates the behaviour of a target-controlled infusion pump. It is similar to other existing programs, such as TIVA trainer on PC's, and iTIVA on smartphones. But the major differences are: SimTIVA is completely free; and also it can be run on any browser, on computers and smartphones. Origin of the project The idea started in October 2020, almost one year ago. At that time, I have already developed a paediatric calculator app, which has branched off into anaesthetist's and paediatric intensivist's versions (you can read more about the paediatric calculator project here ). I wanted to use the experience for something else, something more.  The clinical question is like this. If you give propofol, after a bolus, it enters the bloodstream and will eventually reach the brain (the effect site) and exert its anaesthetic effect. The plasma concentration and the effect site concentration are expressed as CP and CE respectively
Read more

Major Update

 Today marks the major update of Simtiva to V4. A long hiatus occurred between V3 and V4, the development of this change was in progress for one year. The main reason for the time spent in development was the introduction of a "complex mode", or a dual mode, which propofol and opioid (remifentanil or fentanyl) simulations can be run simultaneously. The unique advantage of having a "complex mode" is to explore the pharmacodynamic (PD) interaction between these the hypnotic-analgesic combination. A preset endpoint, the probability of tolerance to laryngoscopy (PTOL) was chosen as the measure to quantify the combined effect of these two drugs. A isobologram chart allows the user to explore different combinations of propofol-remifentanil to achieve the exact same PD effect along the same isobole curve. Moreover, the isobologram chart is sensitive to time, as time progresses, the current time point, as marked by a bright red dot, will move on the screen, with the past an
Read more

Progressive Web App: Why?

SimTIVA is a progressive web app (PWA). For those unfamiliar with this term, PWA's are are web apps built and enhanced with modern APIs to deliver enhanced capabilities, reliability, and installability while reaching anyone, anywhere, on any device, all with a single codebase (from web.dev). Why progressive web app and not just an ordinary app? Users are often confused by this question, why isn't SimTIVA put on App Stores (Google Play, Apple App Store) like many other apps? In fact, modern web browser technology has become so mature in recent years that a "web app" can function within the browser window very much like an app you install from App Store on your smartphones. The trend is quite remarkable. If you have experienced using some of these progressive web app products, such as Google News, or Spotify Web Player, the web app looks and works like an app you install from the App Store. The major advantages of having SimTIVA as a web app are: No restrictions imposed
Read more